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About the study In the current study, researchers investigate how alterations in TrkB signaling in iSPNs and changes in the metabolism of glutathione could impact dopamine levels, progressive neuronal degeneration, and the onset of motor dysfunction in Huntingtons disease

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doi: 10.1208/aapsj080354 85 TenneyJ

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One of these mechanisms is through the activation of transcription factors, such as nuclear factor erythroid 2 (NRF2), which promotes the expression of genes involved in oxidative stress response

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