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Untreated cholelithiasis can lead to gallbladder cancer (though rare) or chronic inflammation that affects nearby organs

Tumor cells use microtubules to assemble purinosomes when IMP is deficient, a crucial adaptive mechanism that enables cancer cells to respond to purine scarcity

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ER Calcium Depletion and Unfolded Protein Response Chronic ethanol exposure also stimulates the release of calcium from the ER via inositol 1,4,5-trisphosphate receptors (IP 3 Rs) and ryanodine receptors (RyRs), leading to ER calcium depletion and the induction of ER stress