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These cytokines are mechanistically relevant, as activating the TNF- signaling pathway leads to hypertension, atherogenesis, vascular dysfunction, and unfavorable cardiac remodeling following MI [48], while IFN- contributes to the progression of atherosclerotic CVDs through the JAK/STAT pathway [49]

This is because vitamin B12 acts as a cofactor for neurotransmitters like serotonin and dopamine, both of which are key regulators of mood and emotion

These biological shifts, rather than just lifestyle habits, are why traditional weight management strategies often become less effective during the menopause transition

Your trajectory will be influenced by your starting weight, breastfeeding status, medication choice, dose, activity level, nutrition quality, hormonal recovery, and sleep patterns