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Interruption of normal brain development can also be brought about by endocrine disruption and direct neurotoxicity

Postgraduate Medical Journal , 100 (1179), 35-42

This allows it to effectively avoid degradation by lysosomes and greatly extend the half-life

DOI: 10.1016/s0033-0620(97)80037-0 Eder, K., Felgner, J., Becker, K., & Kluge, H

212 However, in a placebo-controlled trial in 79 men with sexual dysfunction and low DHEA-S ( 34.3 pg/mL) had one-third the risk of hip fracture compared to those with low estradiol levels ( 18.1 pg/mL) during 1618 years of monitoring