DAPT - γ-secretase Inhibitor. CAS# 208255-80-5 Catalog No.:M60023-10S InChi: InChI=1S/C19H12ClN3O2/c20-12-2-1-3-13(9-12)22-18-15-6-7-21-10-16(15)14-5-4-11(19(24)25)8-17(14)23-18/h1-10H
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DAPT - γ-secretase Inhibitor. CAS# 208255-80-5 Catalog No.:M60023-10S InChi: InChI=1S/C19H12ClN3O2/c20-12-2-1-3-13(9-12)22-18-15-6-7-21-10-16(15)14-5-4-11(19(24)25)8-17(14)23-18/h1-10HDAPT, CAS No. 208255 80 5, is a widely used secretase inhibitor and serves as an inhibitor of Notch, a secretase substrate. It can also cause a reduction in A40 and A42 levels in human primary neuronal cells (IC50 ~115 nM for total A and ~200 nM for A42) and in brain extracts, as well as in vivo. Since the Notch pathway is involved in development of many cell types, DAPT is used to modulate Notch activity in ESC iPSC or adult stem cell differentiation
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