Ixabepilone 0160 Obeticholic acid (INT-747)7 (10 mg/kg)

Obeticholic acid (INT-747)7 (10 mg/kg) and HS increases the pulmonary congestion in the animals

thus triggering the unfolded protein response (UPR)

Chemical Name: ({2-[(3-aminopropyl)amino]ethyl}sulfanyl)phosphonic acid

It has minimal activity (IC50 >1 µM) against HDAC4

Miltefosine targets cellular membranes

Ixabepilone 0160 Obeticholic acid (INT-747)7 (10 mg/kg)Ixabepilone (also known as azaepothilone B, or BMS 247550) is an orally bioavailable microtubule inhibitor. Ixabepilone was a semisynthetic analogue of epothilone B with antineoplastic activity. Ixabepilone binds to tubulin and promotes tubulin polymerization and microtubule stabilization, thereby arresting cells in the G2 M phase of the cell cycle and inducing tumor cell apoptosis. This agent demonstrates antineoplastic activity against taxane