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Name: congenital lingual melanotic macules Pigmented lesions of the oral cavity: An Update lingual melanotic macules Differential Diagnosis
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This dramatically extends plasma half-life from ~1015 minutes (native IGF-1) to 2030 hours (LR3 form), with a corresponding increase in bioavailability

Groopman JD, Wild CP, Hasler J et al (1993) Molecular epidemiology of aflatoxin exposures: validation of aflatoxin-N7-guanine levels in urine as a biomarker in experimental rat models and humans