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Trimetrexate - CAS# 52128-35-5 60276 C[C@@H](C[C@H](CC1C=CC(=CC=1)C1C=CC=CC=1)NC(=O)CCC([O-])=O)C(=O)OCC

Trimetrexate - CAS# 52128-35-5 60276 C[C@@H](C[C@H](CC1C=CC(=CC=1)C1C=CC=CC=1)NC(=O)CCC([O-])=O)C(=O)OCC

Name: Trimetrexate - CAS# 52128-35-5 60276 C[C@@H](C[C@H](CC1C=CC(=CC=1)C1C=CC=CC=1)NC(=O)CCC([O-])=O)C(=O)OCC
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Trimetrexate - CAS# 52128-35-5 60276 C[C@@H](C[C@H](CC1C=CC(=CC=1)C1C=CC=CC=1)NC(=O)CCC([O-])=O)C(=O)OCCTrimetrexate is a quinazoline derivative. It is a dihydrofolate reductase inhibitor. It has been used with leucovorin in treating pneumocystis pneumonia. It has been investigated for use in treating leiomyosarcoma. It is a methotrexate (MTX) analog that is active against transport deficient MTX resistant tumor cells that overcome the acquired and natural resistance to methotrexate. Other uses include skin lymphoma. Product information CAS Number:

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C[C@@H](C[C@H](CC1C=CC(=CC=1)C1C=CC=CC=1)NC(=O)CCC([O-])=O)C(=O)OCC

Martindale C

InChiKey: VERWOWGGCGHDQE-UHFFFAOYSA-N

Polyamines are involved in nucleosome oligomerization and DNA conformation

InChiKey: HGXSLPIXNPASGZ-UHFFFAOYSA-N

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