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Gradual changes in appearance over days or weeks are a normal signal that the reconstituted solution is reaching the end of its useful life

Combining retatrutide with lifestyle changes such as diet and exercise enhances effectiveness

Dehydration can initially cause the body to retain water, but once hydration levels are restored, the body may release this retained fluid through increased urination

Water retention and inflammation from new exercise: If resistance training has been introduced alongside dietary changes, short-term fluid retention and muscle inflammation can cause the scales to rise or remain static, even as body fat is being lost

"There'll be patients that need to continue [semaglutide injections] at the same dose indefinitely," Houston Methodist's Dr