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SKI-II - CAS# 312636-16-1 0211 126(14):2705-9

SKI-II - CAS# 312636-16-1 0211 126(14):2705-9

Name: SKI-II - CAS# 312636-16-1 0211 126(14):2705-9
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SKI-II - CAS# 312636-16-1 0211 126(14):2705-9SKI II, CAS No. 312636 16 1, is a selective non lipid inhibitor of sphingosine kinase (IC50 = 0. 5 M). nhibits acute myelogenous leukemia cell growth in vitro and in vivo. SKI II was more efficient than two known SphK1 inhibitors SK1 I and FTY720 in inhibiting AML cells. Meanwhile, it induced dramatic apoptosis in above AML cells, and the cytotoxicity by SKI II was almost reversed by the general caspase inhibitor z VAD fmk. SKI II treatment inhibited

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Description

126(14):2705-9

Sugiyama T

PubMed PMID: 26413912

Smiles: CCOC(=O)CC1C(OC)=C(OC)C(=CC=1C(=O)CCCCCCC)OC

8 μM in the region Arg363-Ile381

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