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And as we have seen with other brands facing the loss of exclusivity, manufacturers have enormous incentives to engage in tactics to artificially extend patent protection well beyond what policymakers intended. As a result, he says brand manufacturers could significantly delay generic entry and great cost and access barriers for patients

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The estimated half-life is several hours based on animal data, though precise pharmacokinetic characterization remains incompletea limitation that underscores why human clinical trials would be essential to validate any therapeutic potential

Rarely, severe constipation or intestinal slowing (ileus or bowel obstruction) can occur

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