T-5224 Catalog No.:M8650-2 1-3H3/t12-

1-3H3/t12-

] and decreased mouse apomorphine-induced climbing (MED = 100 mg/kg i

FC(F)(F)C1=CC=C(CNC2=CC=C(CC3=CNC4=NC=C(Cl)C=C34)C=N2)C=N1

thus indicating a potential application of SAE inhibitors in treating MYC-amplified tumors

6-tetrahydro-3a

T-5224 Catalog No.:M8650-2 1-3H3/t12-T 5224 is a selective inhibitor of c Fos activator protein 1. T 5224 ameliorates liver injury and improves survival through decreasing production of proinflammatory cytokines and chemokines in endotoxemic mice. T 5224 has been investigated in phase II human clinical trials. T 5224 may be a promising new treatment for septic kidney injury. Activator protein 1 (AP 1) is a pivotal transcription factor that regulates a wide range of cellular processes