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What Science Says Last Updated: Nov 13, 2025

Serious side effects are rare but real

Step 5 Ongoing dose titration , follow-up check-ins, and side effect support keep your treatment safe and on track throughout your treatment

Tirzepatide became the first dual GLP/GLP-1 receptor agonist to gain FDA approval for treating T2DM in 2022 and obesity in 2023 [ Table 2 ]

Time-to-onset analysis of NAEs associated with GLP-1 RAs The median time-to-onset of NAEs for all GLP-1 RAs was 31 days (interquartile range [IQR] 7123), with 46.25% occurring within the first 30 days of treatment initiation (Table S6, Figure S2)