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In a 2025 analysis from the DO-HEALTH trial, led in part by Dr

Conclusion The oral GLP-1 analogue semaglutide is a new drug that adds several benefits to diabetes treatment in addition to blood glucose control

Nonetheless, efficacy is varies across products and patient subgroups

Each data point represents one donor

This approach reportedly promoted tolerogenic dendritic cells, while calcitriol reduced disease severity, reflected by improved clinical scores, reduced cartilage proteoglycan loss, and decreased bone damage, supported by high-resolution microcomputed tomography and histomorphometry analysis [152]