SB 415286 astatin 2017 Oct 30

2017 Oct 30

106:152-168

Smiles: CC1=C(/C=C2/C3=CC(F)=CC=C3NC/2=O)NC(C)=C1C(=O)NC[C@H](O)CN1CCOCC1

PubMed PMID: 23370664

5H2O/c2*21-20-24-16-15(18(29)25-20)12(9-22-16)6-3-10-1-4-11(5-2-10)17(28)23-13(19(30)31)7-8-14(26)27

SB 415286 astatin 2017 Oct 30SB 415286 is a potent and selective cell permeable, ATP competitive inhibitor of GSK3 with an IC50 value of 78 nM (similar potency for GSK3) and a Ki value of 31 nM. Pharmacological GSK 3 inhibitors are potential drugs for the treatment of neurodegenerative diseases, cancer and diabetes. Product information CAS Number: 264218 23 7 Molecular Weight: 359. 72 Formula: C16H10ClN3O5 Chemical Name: 3 [(3 chloro 4 hydroxyphenyl)amino] 4 (2 nitrophenyl) 2,5