EBE-A22 60181 having MTDs in mice and

having MTDs in mice and rats of >150 mg/ kg and 90 mg/kg in rats

Hazarika N

revealing a role for TGFβ signaling mechanism as a repressor of cardiomyocyte fate

Chemical Name: 2-[1-(aminomethyl)cyclohexyl]acetic acid hydrochloride

Chemical Name: (4E)-2-(2-phenylethenyl)-4-[(pyridin-3-yl)methylidene]-4

EBE-A22 60181 having MTDs in mice andEBE A22 is a derivative of PD 153035. EBE A22, has no effect on EGF R TK but maintains a high cytotoxic profile. EBE A22 binds to DNA and behave as typical intercalating agents. EBE A22 unwinds supercoiled plasmid, stabilizes duplex DNA against heat denaturation, and produces negative CD and ELD signals, as expected for an intercalating agent. EBE A22, but not PD153035, interacts preferentially with GC rich sequences and discriminates against