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Statistical analysis After analysis of variance (one-way ANOVA), data were tested for statistically significant differences between the groups (before and after 12 and 24 weeks of the treatment) by means of Students t-test for paired and unpaired data, as appropriate

Newsholme, E

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While preclinical studies suggest that metformin enhances radiosensitivity and reduces tumor recurrence, its clinical application remains in early stages, with further studies needed to optimize dosing regimens and understand its full therapeutic potential

Pittsburgh, PA, USA), 100 U/mL penicillin, and 100 g/mL streptomycin at 37 C in a humidified atmosphere of 5% CO 2