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This circadian rhythm is regulated by food intake, and specifically, secretion and biological action of gut derived peptide hormones, including glucose-dependent insulinotropic polypeptide (GIP), glucagon-like peptide-1 (GLP-1), and glucagon-like peptide-2 (GLP-2)

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This enables voltage-dependent Ca 2+ channels (VDCCs) to open and the influx of Ca 2+ results in the exocytosis of insulin from -cells (13)

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Effects of the TRPV1 antagonist ABT-102 on body temperature in healthy volunteers: pharmacokinetic/pharmacodynamic analysis of three phase 1 trials

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