SIR4 Polyclonal Antibody, 100ul Nucleic Acid Amplification Mutations in this gene may

Mutations in this gene may be associated with male infertility and premature ovarian failure in female human patients

Polymorphisms in this gene have been linked to Alzheimer's disease in some populations

in particular

Acyl-coenzyme A thioesterase 4 is an enzyme encoded by the ACOT4 gene in humans and is mapped to chromosome 14

The gene product interacts with certain inflammatory response factors| and polymorphisms of this gene may be involved in the pathogenesis of Alzheimer's disease

SIR4 Polyclonal Antibody, 100ul Nucleic Acid Amplification Mutations in this gene mayThis gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular