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The model was defined by five differential equations: T 1 , T 2 , and T 3 are the amount of drug in the transit compartments, C and P are the amount of drug in the central and peripheral compartments, k a and k el are the first-order absorption and elimination rate constants, k 12 and k 21 are the first-order transfer rate constants between the central and peripheral compartments, V/F is the volume of distribution, F is the bioavailability, and Cp is the drug concentration in the central compartment

10.1053/j.ajkd.2005.03.021

Additionally, TiO@Ru@siRNA downregulated key immunosuppressive factors, upregulated immune cytokines, and activated CD4 and CD8 T lymphocytes, effectively remodeling the immune microenvironment and inhibiting oral cancer growth (Zhou et al

Neurotox Res