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The metastatic niche characteristics vary depending on the specific components considered: the interacting cell types, ECM proteins, survival and self-renewal signals, but mostly the secondary site locations, that can either sustain and foster the metastatic niche, or set a hostile environment for the DTCs (154)

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The expression level of pyruvate dehydrogenase (encoding by aceE ), which catalyzes the reaction from pyruvate to the formation of acetyl-CoA, was only 0.13-fold in MG12345