Hydroxychloroquine (HCQ) - Autophagy and TLR9 Inhibitor. CAS# 747-36-4 Catalog No.:M60302-2S Oral dosing with EPZ015666 demonstrated

Oral dosing with EPZ015666 demonstrated dose-dependent antitumor activity in multiple MCL xenograft models

InChi: InChI=1S/C27H41NO2/c1-15-11-24-25(28-14-15)17(3)27(30-24)10-8-20-21-6-5-18-12-19(29)7-9-26(18

EphA2 targeted chemotherapy using an antibody drug conjugate in endometrial carcinoma

2002466-63-7 (2 HCl+4H2O)

Popovicimuller Janeta

Hydroxychloroquine (HCQ) - Autophagy and TLR9 Inhibitor. CAS# 747-36-4 Catalog No.:M60302-2S Oral dosing with EPZ015666 demonstratedHydroxychloroquine (HCQ), CAS No. 747 36 4, is a potent autophagy inhibitor and TLR9 inhibitor. It prevents lysosomal acidification, thereby interfering with a key step in the autophagic process. In cancer cells, HCQ treatment has been shown to cause increased apoptosis, tumor regression, and delay in tumor recurrence. HCQ was an effective growth inhibitor of human RCC cell lines, inhibiting growth, promoting apoptosis, and effecting cellular