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Furthermore, negative affect related to alcohol withdrawal can be examined in animals by conditioned place aversion and anxiety measures (e.g., elevated plus maze, time in the center of the open field) (Valdez et al., 2002

Being an electron donor required for the reduction of oxidized compounds, NADPH is largely produced for a range of redox reactions including reductive biosynthesis (e.g

Methods Enzymol 300:21926 Orlowski M, Karkowsky A (1976) Glutathione metabolism and some possible functions of glutathione in the nervous system

The primary outcome was modified Rankin Scale (mRS) score 0 to 1 at 90 days