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Adjustment Phase After the initial phase, the dose is usually increased to 5 mg once a week for 4 weeks, followed by a second increase to 7.5 mg once a week

By that point, steady state should be well-established, and continued significant appetite return before day seven suggests the dose may genuinely be insufficient for your metabolism and body composition

Some researchers find that the benefits of split dosing become less pronounced over time as their bodies adjust to the drug entirely

In animal studies, MOTS-c administration has been found to increase exercise capacity and improve metabolic parameters independent of activity levels

Most patients report reduced appetite and earlier satiety within the first few days of the initial injection