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Although these drugs undergo rigorous testing for safety and efficacy before approval, long-term effects may not be fully known

10.1056/nejmoa2003697 45

GCH1 plays an essential role in preventing ferroptosis by synthesizing the lipophilic antioxidant BH4, which helps reduce lipid peroxidation, and by remodeling lipid membranes to increase the reduced CoQ10 while decreasing the PUFA-PLs