PROTAC Bcl2 degrader-1 agonist 70)57(87)24(3)96-44)98-39-11-8-27(15-33(39)68)52(84)50-63(93)75-48(64(94)95)31-18-29(79)19-37(81)45(31)30-13-25(6-9-36(30)80)46(60(90)77-50)74-61(91)47(28)73-59(89)35(20-43(69)82)72-62(49)92
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PROTAC Bcl2 degrader-1 agonist 70)57(87)24(3)96-44)98-39-11-8-27(15-33(39)68)52(84)50-63(93)75-48(64(94)95)31-18-29(79)19-37(81)45(31)30-13-25(6-9-36(30)80)46(60(90)77-50)74-61(91)47(28)73-59(89)35(20-43(69)82)72-62(49)92PROTAC Bcl2 degrader 1 (Compound C5) is a PROTAC, which potently and selectively induces the degradation of Bcl 2 (IC50, 4. 94 M; DC50, 3. 0 M) and Mcl 1 (IC50, 11. 81 M) by introducing the E3 ligase cereblon (CRBN) binding ligand pomalidomide to Mcl 1 Bcl 2 dual inhibitor Nap 1. Product information CAS Number: 2378801 85 3 Molecular Weight: 941. 84 Formula: C45H45BrN6O10S Chemical Name: N' (2 {8 [(4 bromophenyl)sulfanyl] 2, 4 dioxo 3 azatricyclo[7.
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