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Curcumin and (-)- epigallocatechin-3-gallate protect murine min6 pancreatic beta-cells against iron toxicity and erastin-induced ferroptosis

[DOI] [PMC free article] [PubMed] [Google Scholar] 307.Wang Q, Gao H, Clark KM, Mugisha CS, Davis K, Tang JP, et al

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The BBB consists of endothelial cells held by tight junctions and adherens junctions, a basement membrane that serves as a scaffold, pericytes that surround the vessels, and astrocytic end feet encircling them both (Maiuolo et al., 2018)

The long-term consequence is accelerated desensitization over multiple cycles, which progressively increases the dose required for equivalent effect