DDR1-IN-1 - CAS# 1449685-96-4 size:10mg solid SCHEMBL15506294
DKK45.00
DKK92.00
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DDR1-IN-1 - CAS# 1449685-96-4 size:10mg solid SCHEMBL15506294DDR1 IN 1, CAS No. 1449685 96 4, is a potent and selective DDR1 inhibitor with IC50 of 105 nM, about 3 fold selectivity over DDR2. DDR1 IN 1 binds to DDR1 in the 'DFG out' conformation and inhibits DDR1 autophosphorylation in cells at submicromolar concentrations with good selectivity as assessed against a panel of 451 kinases measured. DDR1 IN 1 provides a useful pharmacological probe for DDR1 dependent signal transduction. The DDR1 receptor tyrosine
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