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No other injectable compound has produced a 24.2% average body weight reduction in a controlled 48-week trial setting

Clinical studies Despite their thriving role in the treatment of obesity 214 , only seven studies investigated the effects of GLP-1RAs in eating disorders (Table 6), including some on their psychopathology in comorbid obesity 215,216,217 and others specifically in binge-eating disorder (BED) 217,218,219,220 , and we could not find any ongoing trial in this area

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In clinical settings, several trialsnotably the longer one, with sitagliptindid not show an increased risk for ischemic events [60], but the encouraging results from basic science were not yet translated into clinical evidence, probably due the pleiotropic enzymatic effects of DPP4 [159, 160]