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We found a significant reduction in the GSH/GSSG ratio in the GR-deficient strain compared to the WT strain ( P = 0.0011), indicating severe oxidative stress (Figure 6A)

A study on diet-induced obese (DIO) mice demonstrated that a reduced-calorie diet combined with NNMT inhibition resulted in a unique microbiome composition, suggesting potential applications for 5-Amino-1MQ in gut microbiota-related metabolic research

The RCS model was used to show the shape of these associations between homocysteine levels and ASD and between homocysteine and folate levels and the severity of ASD symptoms, respectively

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