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Several GDF-15 agonists are undergoing early phase clinical trials including NNC0247-0829 and JNJ-9090/CIN-109

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Semaglutide An ongoing phase 2 trial (NCT02970942) is currently investigating the efficacy and safety of three doses of subcutaneous semaglutide once-daily versus placebo in subjects with NASH

The recently introduced peptides GLP1/GIP medication can be administered once weekly and have demonstrated substantially improved weight-losing effects within a tolerable safety margin in a series of STEP and SURPASS trials