CHR-6494 - CAS# 1333377-65-3 Catalog No.:M10283-2 Chemical Name: 2-(5-chloro-2-fluorophenyl)-N-4-pyridinyl-4-pteridinamine

Chemical Name: 2-(5-chloro-2-fluorophenyl)-N-4-pyridinyl-4-pteridinamine

providing biochemical evidence of NMDA receptor antagonism in vivo

and induces apoptosis through activation of caspase-3 and cleavage of poly(ADP-ribose) polymerase (PARP)

It inhibits proliferation in a variety of cancer cell lines

Gamabufagin

CHR-6494 - CAS# 1333377-65-3 Catalog No.:M10283-2 Chemical Name: 2-(5-chloro-2-fluorophenyl)-N-4-pyridinyl-4-pteridinamineCHR 6494 is a potent and selective histone kinase Haspin inhibitor. CHR 6494 reduces H3T3ph levels in a dose dependent manner and causes a mitotic catastrophe characterized by metaphase misalignment, spindle abnormalities and centrosome amplification. CHR 6494 shows antitumor potential in xenografted nude mice without any observed toxicity. Thus, CHR 6494 is a first in class Haspin inhibitor with a wide spectrum of anticancer effects that merits