AL 082D06 - CAS# 256925-03-8 043 Chemical genetics screen for enhancers

Chemical genetics screen for enhancers of rapamycin identifies a specific inhibitor of an SCF family E3 ubiquitin ligase

MDA-MB-435

5-a]pyrazin-1-yl)naphthalen-1-yl)-3-(3-(trifluoromethyl)phenyl)urea

Chemical Name: 5-(3-chlorophenyl)-N-(4-(morpholinomethyl)phenyl)furan-2-carboxamide

JNJ-42041935 was used at 10 µM final concentration in vitro and in cellular assays

AL 082D06 - CAS# 256925-03-8 043 Chemical genetics screen for enhancersAL 082D06, CAS No. 256925 03 8, also known as D 06, is a nonsteroidal glucocorticoid receptor antagonist. AL082D06 binds specifically to GR with no measurable binding affinity to the progesterone receptor. AL082D06 binds with nanomolar affinity to the GR and has no detectable binding affinity for the highly related receptors for mineralocorticoids, androgens, estrogens, and progestins. AL082D06 inhibits glucocorticoid mediated transcriptional