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For the Medicare Part D Drug Inflation Rebate Program, this rulemaking proposes to clarify what CPI-U data CMS would use in the event CPI-U data are unavailable, a modification to the methodology finalized in the CY 2026 PFS final rule to account for 340B-eligible units for AIDS Drug Assistance Programs (ADAPs), and to require all providers and suppliers that are covered entities as defined under 10.3 (hereinafter collectively 340B providers unless otherwise noted) to submit data elements from their Part D 340B claims to the 340B repository beginning in 2027

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Based on our analysis for both the complicated and uncomplicated diagnoses combined with our review of all the cases in the MS-DRGs, we believe the findings support a prior comment, as summarized in the FY 2023 IPPS/LTCH PPS final rule (87 FR 48849), that clinically, both localized and generalized peritonitis in association with an appendectomy require the same level of patient care, including extensive intraoperative irrigation at the surgical site, direct inspection or imaging of the abdomen to identify possible abscess, use of intravenous antibiotics, and prolonged monitoring

For most researchers, the 2ml option hits the sweet spot between measurement precision and practical injection volumes

Bibcode:1941JAChS..63.2284M