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Fifty-eight patients with ST-segment-elevation MI and thrombolysis were randomized to receive either saline (n = 40) or exenatide (n = 18, 10 g SC and 10 g as an IV bolus 5 min before the onset of reperfusion plus 10 g SC twice daily on the following 2 days) to evaluate whether this GLP-1R agonist could reduce the area of necrosis

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Whether such combinations would behave additively, synergistically, or otherwise is a research question, not an established finding

After: Wakes refreshed, workouts feel fluid, soreness resolves in 24-48 hours

There was no head-to-head trial directly comparing these antidiabetic drug classes