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UBA1 Polyclonal Antibody, 50ul Sealing Film This enzyme is a ubiquitously

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UBA1 Polyclonal Antibody, 50ul Sealing Film This enzyme is a ubiquitouslyUbiquitin like modifier activating enzyme 1 encoded by UBA1 catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation. This gene complements an X linked mouse temperature sensitive defect in DNA synthesis, and thus may function in DNA repair. It is part of a gene cluster on chromosome Xp11. 3. Alternatively spliced transcript variants that encode the same protein have been described.

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Description

This enzyme is a ubiquitously expressed thiolester hydrolase

which is a member of the APP (amyloid precursor protein) family including APP

Knockout studies in mice also suggest a role of this protein in protecting neurons from apoptosis by stimulating antioxidative pathways

Translocations with the ETV6 gene are causes of myelodysplastic syndrome with basophilia

This protein is expressed at high levels on the apical side of mature enterocytes in the small intestine

UBA1 Polyclonal Antibody, 50ul Sealing Film This enzyme is a ubiquitouslyUbiquitin like modifier activating enzyme 1 encoded by UBA1 catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation. This gene complements an X linked mouse temperature sensitive defect in DNA synthesis, and thus may function in DNA repair. It is part of a gene cluster on chromosome Xp11. 3. Alternatively spliced transcript variants that encode the same protein have been described.

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