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Distinctive pharmacological approaches designed for NAD-complementation or targeting NAD-centric proteins (SIRT1, SIRT2, PARP-1, GPR109a, and CD38) are outlined towards determining which approach may work best in the context of clinical application

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The transverse relaxation in the rotating frame R 1 was then converted to R 2 as described previously 50,51 using the formula in which = arctan(1/) is the tilt angle between the static magnetic field and the effective field in the rotating frame

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