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10.1016/j.mam.2012.05.008 118 HuangY.WangX.WangJ.WuF.SuiY.YangL.et al (2013)

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The most significant published evidence to date comes from a phase 2 randomised controlled trial (Jastreboff et al., New England Journal of Medicine , 2023), which demonstrated substantial dose-dependent weight loss in adults with obesity over 24 weeks, with continued weight reduction observed at 48 weeks