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However, even the purest peptide can be compromised by improper handling

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Endotoxins activate specific membrane receptors termed Toll-like receptors that are members of a class of pro-inflammatory receptors hat recognize pro-inflammatory molecules termed pattern-associated molecular patterns or PAMPS that in turn can activate genes that initiate inflammatory cascades in the host [49, 65]

[0026] In the present invention, an acidic TFA solution is to be used to remove Mmt and Mtt protecting groups 6-12 times, which increases the complexity of the operation