PARP8 Polyclonal Antibody, 20ul Gloves The encoded protein is also

The encoded protein is also a candidate tumor suppressor protein| and aberrant promoter methylation of this gene may play a role in cervical cancer

An important paralog of this gene is SNRNP200

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Subfamily A contains 12 genes| subfamily B contains 7 genes and 2 pseudogenes| and the more distantly related subfamily C contains 3 genes

They promote DNA binding and transactivation of p53-family proteins on the promoters of proapoptotic genes

PARP8 Polyclonal Antibody, 20ul Gloves The encoded protein is alsoCatalytic activity: NAD(+) + (ADP D ribosyl)(n) acceptor = nicotinamide + (ADP D ribosyl)(n+1) acceptor.,PTM: Phosphorylated upon DNA damage, probably by ATM or ATR.,sequence Contaminating sequence. Potential poly A sequence.,Contains 1 PARP catalytic domain.,