p53(Phospho Ser376) Polyclonal Antibody, 100ul Protein Research Methylation of the CpG island

Methylation of the CpG island leads to transcriptional silencing of this gene

Protein phosphatase 2A holoenzymes are heterotrimeric proteins composed of a structural subunit A

GO annotations related to this gene include damaged DNA binding and DNA-directed DNA polymerase activity

PIAS4 also alters the nuclear localization

tissue specificity:Predominantly expressed in kidney and liver

p53(Phospho Ser376) Polyclonal Antibody, 100ul Protein Research Methylation of the CpG islandThis gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li Fraumeni syndrome.