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These results suggested that AMPK pathway was involved in the metformin-induced upregulation of GLP-1R level and PKA phosphorylation in PA-impaired HUVECs

First, the causal direction in human studies remains ambiguous: it is unclear whether gut dysbiosis is a driver of OA or a consequence of its associated factors, such as reduced physical activity, diet changes, or chronic medication use

GLP-1 agonists are medications that help manage your blood sugar levels and promote weight loss

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