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2-Acetylamino-3-[4-(2-acetylamino-2-carboxyethylsulfanylcarbonylamino)- phenylcarbamoylsulfanyl]propionic acid and its derivatives as a novel class of glutathione reductase inhibitors

Advances in medical technology, such as precision-guided imaging, have improved treatment outcomes and reduced risks associated with surgery

doi: 10.1001/archinte.152.8.1611 147 CameronBFlamandLJuwanaHMiddeldorpJNaingZRawlinsonWet al

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Overall, we conclude that PC patients with low expression of VRK2 are sensitive to GSH-targeting therapy, while PC patients with high expression of VRK2 are re-sensitive to GSH-targeting therapy following VRK2 inhibition, indicating genetic aberrance of VRK2 expression stratifies the response of PC to metabolism-targeted therapies