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It is important to note that the findings discussed below come primarily from laboratory and preclinical research

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It should be administered after veterinary assistance to avoid any problem

Abbreviations MAFLD: Metabolic dysfunction-associated fatty liver disease MAFL: Metabolic Associated Fatty Liver MASH: Metabolic Associated Steatohepatitis MASLD: Metabolic Dysfunction-Associated Steatotic Liver Disease NAFLD: Non-Alcoholic Fatty Liver Disease NASH: Non-Alcoholic Steatohepatititis MetS: Metabolic syndrome AMPK: 5 adenosine monophosphate-activated protein kinase T2DM: Type 2 diabetes mellitus SESN: Sestrin miRNA: MicroRNAs ADAR: Adenosine deaminases acting on RNA FGF21: Fibroblast growth factor 21 FABP1: Fatty acid-binding protein 1 IL-6: Interleukin-6 PLIN: Perilipin LAMP1: Lysosomal associated membrane protein 1 CaMKK: Calcium/Calmodulin-Dependent Protein Kinase Kinase CREB: cAMP Response Element-Binding Protein ACC: Acetyl-CoA carboxylase CPT1: Carnitine Palmitoyltransferase 1 SREBP1c: Sterol Regulatory Element-Binding Protein 1c Scd1: Stearoyl-CoA desaturase 1 VEGFB: Vascular Endothelial Growth Factor B mTORC1: Mechanistic target of rapamycin complex 1 mTORC2: Mechanistic target of rapamycin complex 2 Akt: Protein kinase B Nrf2: Nuclear factor erythroid 2-related factor 2 Keap1: Kelch-like ECH-associated protein 1 AREs: Antioxidant response elements LC3: Microtubule-associated protein 1 light chain 3 SQSTM1: Sequestosome 1 ATP6V0D1: Lysosomal H-transporting ATPase CTSD: Cathepsin D PPAR: Peroxisome proliferator-activated receptor Mfn-2: Mitofusin-2 GPX4: Glutathione peroxidase 4 GSH: Glutathione ROS: Reactive oxygen species PUFAs: Polyunsaturated fatty acids ACSL4: Acyl-CoA synthetase long-chain family member 4 ALOX15: Arachidonate 15-lipoxygenase Nrg4: Neuregulin 4 EGF: Epidermal growth factor ErbB4: Epidermal Growth Factor Receptor 4 cGAS: Cyclic guanosine monophosphate-adenosine monophosphate synthase STING: Stimulator of interferon genes STAT5a: Signal transducer and activator of transcription 5a LXR: Liver X receptor FASN: Fatty acid synthase TG: Triglycerides IR: Insulin resistance TNF-: Tumor necrosis factor- HCC: Hepatocellular carcinoma PDM: Peridroplet mitochondria WB: Western blot IPA: Ingenuity Pathway Analysis FFA: Free fatty acid HFD: High fatty diet PI3K: Phosphatidylinositol 3-kinase RXR: Retinoid X receptor SCAP: SREBP cleavage-activating protein SRE: Sterol regulatory element NPC: Nuclear pore complex RISC: RNA-induced silencing complex IRF3: Interferon regulatory factor 3 NF-B: Nuclear factor kappa-B c/EBP: CCAAT-enhancer-binding protein HIF-1: Hypoxia-Inducible Factor 1 FOXO: Forkhead Box O ALT: Alanine Aminotransferase AST: Aspartate Aminotransferase LBP: Leucine-binding Pocket MCD: MethionineCholine-deficient Lip-1: Liproxstatin-1 PPRE: Peroxisome Proliferator Response Element STING: Stimulator of Interferon Genes TBK1: TANK-Binding Kinase 1 TAG: Triacylglycerols SE: Sterol Esters GADD: Growth Arrest and DNA Damage-Inducible Gene ULK1: Unc-51-like Kinase 1 NQO1: NAD(P)H Quinone Dehydrogenase 1 GST: Glutathione S-Transferase References Abdelhameed F, Kite C, Lagojda L, Dallaway A, Chatha KK, Chaggar SS, et al