Phospho-Bim (S59) Polyclonal Antibody, 100ul In vitro Transcription Members of this family can

Members of this family can interact with the elongin B-C adapter complex via their SOCS box domain and further complex with the cullin and ring box proteins to form E3 ubiquitin ligase complexes

Plays a role in antigen receptor signaling for both clonal expansion and deletion in lymphoid cells

The extracellular region contains a meprin-A5 antigen-PTP (MAM) domain

This particular family member contains domains which are characteristic of the GAP1 subfamily of RasGAP proteins but

CREB3 (cAMP responsive element binding protein 3) encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins

Phospho-Bim (S59) Polyclonal Antibody, 100ul In vitro Transcription Members of this family canBim Bod is a pro apoptotic protein belonging to the BH3 only group of Bcl 2 family members including Bad, Bid, Bik, Hrk, and Noxa that contain a BH3 domain but lack other conserved BH1 or BH2 domains. Bim induces apoptosis by binding to and antagonizing anti apoptotic members of the Bcl 2 family. Interactions have been observed with Bcl 2, Bcl xL, Mcl 1, Bcl w, Bfl 1, and BHRF 1. Bim functions in regulating apoptosis associated with thymocyte negative