GLI2 Polyclonal Antibody, 100ul In vitro Assessment Three transcript variants encoding different

Three transcript variants encoding different isoforms have been found for MOB1B

This protein may tightly associate or interact with the pyruvate dehydrogenase complex

Overexpression of this gene may play a role in leukemogenesis| and the encoded protein has been implicated in acute myeloid leukemia as a fusion partner of the myeloid-lymphoid leukemia protein

Defects in ACTA2 cause aortic aneurysm familial thoracic type 6

Mutations in this gene are the cause of autosomal dominant Robinow syndrome

GLI2 Polyclonal Antibody, 100ul In vitro Assessment Three transcript variants encoding differentThis gene encodes a protein which belongs to the C2H2 type zinc finger protein subclass of the Gli family. Members of this subclass are characterized as transcription factors which bind DNA through zinc finger motifs. These motifs contain conserved H C links. Gli family zinc finger proteins are mediators of Sonic hedgehog (Shh) signaling and they are implicated as potent oncogenes in the embryonal carcinoma cell. The protein encoded by this gene