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Studies of tirzepatide (the active ingredient in Zepbound and Mounjaro) have found a similar pattern

If you are supplementing with B12 make sure to use Methylcobalamin and not Cyanocobalamin

The headline results, as released in the Eli Lilly investor communication and aligned with the study design paper by Giblin and colleagues published in Diabetes, Obesity and Metabolism in 2026, are unusually strong for a Phase 3 obesity trial: Retatrutide 12 mg: mean body-weight reduction of 28.7 percent, roughly 32.3 kg (about 71.2 lbs) from baseline

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