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Altered Mitochondrial Function in MASLD: Key Features and Promising Therapeutic Approaches

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Sufficient levels of -KG favor these demethylation reactions, whereas accumulation of certain metabolites such as 2-hydroxyglutarate, succinate, or fumarate (which can occur owing to IDH mutations or SDH/fumarase deficiencies) competitively inhibits -KG-dependent enzymes 12,46,47

301 The potential mechanisms related to gut microbiome activities and IR are very complex, and numerous studies with contradictory results render it difficult to identify clear mechanistic pathways

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