CD55 Polyclonal Antibody, 50ul[BT-AP01775] Metabolic enzymes Three alternatively spliced variants encoding

Three alternatively spliced variants encoding different isoforms have been described for this gene

Mutations in this gene have been linked to severe spermatogenic failure and infertility in males

and a short C-terminal extracellular region

The protein encoded by this gene is a member of a small family of proteins which bind single stranded DNA/RNA

The large extracellular carboxyterminal domain contains a pentapeptide consensus sequence characteristic of members of the zinc-binding metalloproteinase superfamily

CD55 Polyclonal Antibody, 50ul[BT-AP01775] Metabolic enzymes Three alternatively spliced variants encodingDDIT3 encodes a member of the CCAAT enhancer binding protein (C EBP) family of transcription factors. DNA damage inducible transcript 3 functions as a dominant negative inhibitor by forming heterodimers with other C EBP members, such as C EBP and LAP (liver activator protein), and preventing their DNA binding activity. The protein is implicated in adipogenesis and erythropoiesis, is activated by endoplasmic reticulum stress, and promotes apoptosis.