Rb(Phospho Ser249) Polyclonal Antibody, 50ul Immune Repertoire Sequencing Suppresses Src-dependent tyrosine phosphorylation and

Suppresses Src-dependent tyrosine phosphorylation and activation of PDPK1 and its downstream signaling

these family members can likely stimulate calmodulin-dependent kinase II and the protein phosphatase calcineurin

The duplicated copy of this gene is incomplete and is a pseudogene which is transcribed but does not encode a protein

More than 30 loci (SPG1-33) have been implicated in hereditary spastic paraplegia diseases

Interacts with CUL7

Rb(Phospho Ser249) Polyclonal Antibody, 50ul Immune Repertoire Sequencing Suppresses Src-dependent tyrosine phosphorylation andThe protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma.